Current team member
I first joined the Davis Lab in 2008 when I completed a lab-based dissertation as part of my undergraduate master’s in Molecular and Cellular Biochemistry. This work focussed on the stoichiometry of the G protein-coupled receptor (GPCR) CCR5, a major drug target due to its role in HIV infection. I subsequently returned to begin my D.Phil in 2009, investigating the family-specific behaviour of GPCRs and the evolutionary contributions to their stoichiometry. This involved extensive use of established and novel approaches to bioluminescence resonance energy transfer as well as single-molecule imaging in collaboration with the David Klenerman lab, University of Cambridge.
Since completing my D.Phil in 2014, I have remained in the Davis lab as a post-doc but have entirely changed the focus of my work, and am now undertaking a structural study on the T-cell receptor and an investigation of triggering by Fc receptors in collaboration with the Christian Eggeling lab.
I was recently awarded a Sir Henry Wellcome Postdoctoral Fellowship as a direct result of the outstanding scientific environment that I have been privileged to be exposed to within the Davis lab, and thanks to generous assistance from Simon himself, though this sadly means I will be leaving the Davis group at the end of my current position.