About Simon

I grew up in South Australia and completed a science degree at Flinders University in Adelaide in 1982.

My PhD studies on Dictyostelium developmental biochemistry, also at Flinders, were supervised by John Wheldrake. It had been John who suggested, in one of his undergraduate classes, that all biochemistry students should read “The Double Helix” by JD Watson (Fig. 1). I read it and learnt two things: the thrill of discovery and that, when it really counts, it’s not about where you’re from but simply a matter of how good your ideas are versus the next person’s. Under John’s influence I developed an abiding interest in the cell surface and became particularly impressed by the pioneering work of Alan Williams and Neil Barclay on the T-cell surface at the UK Medical Research Council (MRC) Cellular Immunology Unit in Oxford. During a brief stint in California at UC San Diego as a visiting student in the laboratories of Hud Freeze and Ajit Varki, I became aware of the power of molecular biological techniques and the need to do medically-oriented research as a long-term career strategy.

In 1987 I secured a post-doctoral position in Alan William’s laboratory and thereafter was able to focus on T-cell surface biology myself (Fig. 2,3). Neil had begun introducing into the laboratory approaches for the production of large amounts of high-quality protein for structural and functional studies, and I was the first beneficiary of this. Collaborations with Shinji Ikemizu, Yvonne Jones, Dave Stuart and, in particular, Anton van der Merwe, were subsequently critical to our work. In 1995 I established my own laboratory in what is now the Radcliffe Department of Medicine, and I am now based at the Weatherall Institute of Molecular Medicine, which is led by KJ Patel. I am also a member of the MRC Translational Immune Discovery Unit, directed by Alison Simmons.

Fig. 1:

The Double Helix

Fig. 2

Simon Davis soon after arriving in Oxford in 1989

Davis lab oxford

Fig. 3: Colleagues at the MRC Cellular Immunology Unit

(Back, left to right) Marian Birkeland, Simon Davis, Marion Brown, Neil Barclay; (Front, left to right) Alan Williams, Chamorro Somoza, Albertus Beyers. These people helped write the Leucocyte Antigen Factsbook, Academic Press, 1993.

Scientific highlights have been:

    • Solving the glycosylation problem for glycoprotein crystallization (1993)

    • Crystallizing and determining the structure of the first cell adhesion protein (1992)

    • Identifying the structural basis of weak, specific recognition at the cell surface (1998)

    • The KS model (1996; with PA van der Merwe)

    • Determining the composition of the T-cell surface (2003), and solving GPCR stoichiometry (2015).

Our laboratory’s work is sponsored principally by The Wellcome Trust and also by the MRC.

Witness what was for many years a second occupation:

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