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  2. 1992

Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4

Schockmel GA, Somoza C, Davis SJ, Williams AF, Healey D. (1992), J Exp Med. 175, 301-4

23rd October 19921990-1994 Paper, Papers, Protein InteractionsBy Oliver Lui

Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors

Davis SJ, Schockmel GA, Somoza C, Buck DW, Healey DG, Rieber EP, Reiter C, Williams AF. (1992), Nature. 358, 76-9

23rd October 19921990-1994 Paper, Papers, Protein InteractionsBy Oliver Lui

Abstract The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI. (1992), Nature. 360, 232-9

6th January 19921990-1994 Paper, Protein Interactions, Top 10 PapersBy clearandcreative
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