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  2. 1992
  3. January
  4. 06

Abstract The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI. (1992), Nature. 360, 232-9

6th January 19921990-1994 Paper, Protein Interactions, Top 10 PapersBy clearandcreative
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