CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily

Fennelly JA, Tiwari B, Davis SJ, Evans EJ. (2001), Immunogenetics. 53, 599-602

Abstract

The CD2 subset of the immunoglobulin superfamily consists of a rapidly expanding family of leukocyte cell surface receptors, at least five of which (CD2, CD48, CD58, CD150, and CD244) are involved in lymphocyte activation as either receptors or ligands. Completion of the draft sequence of the human genome offers the possibility of systematically identifying the full set of proteins and interactions of this important family. Here we describe the identification and characterization of the first new member of the subset, CD2F-10, found exclusively by genome searching.

Key figure: Alignments of amino acid sequences generated using the Clustal W algorithm

Comparison of the CD2F-10 extracellular domain to those of CD84 and CS1 and to the first two and the last two IgSF domains of CD229.