James Felce

James is currently a post-doc, working with Simon at the Davis lab in Oxford. He studied for his PhD under Simon’s direction and prior to that he studied Biochemistry for his undergraduate degree here in Oxford too.

James had had an opportunity to work with Simon during his undergraduate degree. He was impressed by the level of support and high quality of the lab, the science, and the general atmosphere and so decided to apply for a PhD position within the lab.

In particular, James found the technical support from the four experienced research assistants very useful in helping him get through the volume of work required for his studies.

James will be leaving Simon’s lab very soon. He’s been awarded a Fellowship with the Wellcome Trust at the Kennedy Institute.

“The WIMM is unusual to foster such a feeling of friendliness and I’ll be sorry to leave. I’ll be leaving some good friends.” – James

Top Ten Papers

A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer

James JR, Oliveira MI, Carmo AM, Iaboni A, Davis SJ. (2006), Nat Methods. 3, 1001-6
Crystal structure of a soluble CD28-Fab complex

Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, Fennelly JA, Vowles C, Hanke T, Walse B, Hünig T, Sørensen P, Stuart DI, Davis SJ. (2005), Nat Immunol. 6, 271-9
The T cell surface – how well do we know it?

Evans EJ, Hene L, Sparks LM, Dong T, Retiere C, Fennelly JA, Manso-Sancho R, Powell J, Braud VM, Rowland-Jones SL, McMichael AJ, Davis SJ. (2003), Immunity. 19, 213-23
The interaction properties of costimulatory molecules revisited

Collins AV, Brodie DW, Gilbert RJ, Iaboni A, Manso-Sancho R, Walse B, Stuart DI, van der Merwe PA, Davis SJ. (2002), Immunity. 17, 201-10
LICOS, a primordial costimulatory ligand?

Brodie D, Collins AV, Iaboni A, Fennelly JA, Sparks LM, Xu XN, van der Merwe PA, Davis SJ. (2000), Curr Biol. 10, 333-6
Structure and dimerization of a soluble form of B7-1

Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ. (2000), Immunity. 12, 51-60
The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2

Davis SJ, Davies EA, Tucknott MG, Jones EY, van der Merwe PA. (1998), Proc Natl Acad Sci U S A. 95, 5490-4
The structure and ligand interactions of CD2: implications for T-cell function

Davis SJ, van der Merwe PA. (1996), Immunol Today. 17, 177-87
Expression of soluble recombinant glycoproteins with predefined glycosylation: application to the crystallization of the T-cell glycoprotein CD2

Davis SJ, Puklavec MJ, Ashford DA, Harlos K, Jones EY, Stuart DI, Williams AF. (1993), Protein Eng. 6, 229-32
Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI. (1992), Nature. 360, 232-9